Cheap flights from Santo Domingo to Panama City
From 600 USD — compare hundreds of airlines
Live fares from 100+ sites — free, with no hidden fees.
About this route
Compare flights from Santo Domingo to Panama City, a about 1,475 km route (around 2h 21m nonstop). We gather live prices from hundreds of airlines and agencies so you can find the cheapest and book on the official site, with no hidden fees. Direct flights are available. Airlines such as Copa Airlines, Condor operate this route.
The airports on this route
About 30 km from central Santo Domingo
Getting around: Taxis, hotel transfers and buses
About 25 km from downtown Panama City
Getting around: Metro + buses, authorized taxis and apps
Copa’s big connection hub: if you’re only connecting you rarely need to leave the airport.
How to get the best price
Airlines on this route
FAQ
What's the cheapest month to fly Santo Domingo to Panama City?
Prices vary by season; use the price calendar to find the cheapest month.
How long is the flight from Santo Domingo to Panama City?
A nonstop flight takes about 2h 21m and covers around 1,475 km. Connecting itineraries take longer.
Are there direct flights from Santo Domingo to Panama City?
Yes, this route has nonstop flights. Filter by "nonstop" to see them.
Which airlines fly from Santo Domingo to Panama City?
Copa Airlines, Condor operate this route, among others. Compare them all in the results.
When should I book Santo Domingo–Panama City flights?
As a rule of thumb, booking 3–8 weeks ahead and avoiding weekends and holidays tends to give the best prices. Use the calendar to spot the cheapest dates.
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Santo Domingo → Panama City · Live fares from 100+ sites — free, with no hidden fees.