Cheap flights from Santo Domingo to Panama City
from 374 US$

From 554 USD — compare hundreds of airlines

We search 100+ flight sitesDirect flights~2h 21mReturn route: Panama City → Santo Domingo

The cheapest month is usually 2026-10 · 374 US$

Live fares from 100+ sites — free, with no hidden fees.

About this route

Compare flights from Santo Domingo to Panama City, a about 1,475 km route (around 2h 21m nonstop). We gather live prices from hundreds of airlines and agencies so you can find the cheapest and book on the official site, with no hidden fees. Direct flights are available. Airlines such as Copa Airlines, Condor operate this route.

Nonstop time

2h 21m

Distance

1,475 km

Stops

Nonstop

Airlines

The airports on this route

Santo Domingo

Aeropuerto Internacional Las AméricasSDQ

About 30 km from central Santo Domingo

Getting around: Taxis, hotel transfers and buses

Panama City

Aeropuerto Internacional de TocumenPTY

About 25 km from downtown Panama City

Getting around: Metro + buses, authorized taxis and apps

Copa’s big connection hub: if you’re only connecting you rarely need to leave the airport.

When to buy and when to fly

Prices by date

Fares found by date — cheapest days in green.

See prices for my dates →

374 US$

18/10

380 US$

19/10

380 US$

20/10

380 US$

21/10

380 US$

22/10

380 US$

23/10

380 US$

24/10

386 US$

25/10

How to get the best price

1The sticker price is real — but it moves fastLow fares last hours or days. If the number works, search it today; waiting rarely improves it.

2Buy 4–8 weeks aheadThat window usually holds the best fares; holidays call for even more margin.

3Flexibility = moneyShifting departure 2–3 days can move the fare 100+ US$. Tuesdays and Wednesdays tend to be cheap.

Airlines on this route

Copa Airlines Condor

FAQ

What's the cheapest month to fly Santo Domingo to Panama City?

It's usually 2026-10, from 374 USD. Use the price calendar to compare other dates.

How long is the flight from Santo Domingo to Panama City?

A nonstop flight takes about 2h 21m and covers around 1,475 km. Connecting itineraries take longer.

Are there direct flights from Santo Domingo to Panama City?

Yes, this route has nonstop flights. Filter by "nonstop" to see them.

Which airlines fly from Santo Domingo to Panama City?

Copa Airlines, Condor operate this route, among others. Compare them all in the results.

When should I book Santo Domingo–Panama City flights?

As a rule of thumb, booking 3–8 weeks ahead and avoiding weekends and holidays tends to give the best prices. Use the calendar to spot the cheapest dates.