Cheap flights from Panama City to Mexico City
from 269 US$
From 526 USD — compare hundreds of airlines
The cheapest month is usually 2026-09 · 269 US$
See prices for my dates →Live fares from 100+ sites — free, with no hidden fees.
About this route
Compare flights from Panama City to Mexico City, a about 2,407 km route (around 3h 31m nonstop). We gather live prices from hundreds of airlines and agencies so you can find the cheapest and book on the official site, with no hidden fees. Direct flights are available. Airlines such as Aeromexico, Copa Airlines operate this route.
The airports on this route
About 25 km from downtown Panama City
Getting around: Metro + buses, authorized taxis and apps
Copa’s big connection hub: if you’re only connecting you rarely need to leave the airport.
About 6 km from central Mexico City
Getting around: Metro (Terminal Aérea station), Metrobús Line 4, authorized taxis and apps
Buy taxi rides at the authorized in-terminal counters; the city sits at ~2,240 m.
About 45 km north of Mexico City, in Zumpango
Getting around: Suburban train, direct buses, taxis and apps
Often has attractive fares, but budget a long transfer to the center (1.5h+).
When to buy and when to fly
Prices by date
Fares found by date — cheapest days in green.
How to get the best price
Airlines on this route
FAQ
What's the cheapest month to fly Panama City to Mexico City?
It's usually 2026-09, from 269 USD. Use the price calendar to compare other dates.
How long is the flight from Panama City to Mexico City?
A nonstop flight takes about 3h 31m and covers around 2,407 km. Connecting itineraries take longer.
Are there direct flights from Panama City to Mexico City?
Yes, this route has nonstop flights. Filter by "nonstop" to see them.
Which airlines fly from Panama City to Mexico City?
Aeromexico, Copa Airlines operate this route, among others. Compare them all in the results.
When should I book Panama City–Mexico City flights?
As a rule of thumb, booking 3–8 weeks ahead and avoiding weekends and holidays tends to give the best prices. Use the calendar to spot the cheapest dates.
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Panama City → Mexico City · Live fares from 100+ sites — free, with no hidden fees.