Cheap flights from Panama City to Santiago
From 644 USD — compare hundreds of airlines
About this route
Compare flights from Panama City to Santiago, a about 4,810 km route (around 6h 31m nonstop). We gather live prices from hundreds of airlines and agencies so you can find the cheapest and book on the official site, with no hidden fees. Direct flights are available. Airlines such as Copa Airlines operate this route.
Prices by date
Airlines on this route
FAQ
What's the cheapest month to fly Panama City to Santiago?
It's usually 2026-08, from 341 USD. Use the price calendar to compare other dates.
How long is the flight from Panama City to Santiago?
A nonstop flight takes about 6h 31m and covers around 4,810 km. Connecting itineraries take longer.
Are there direct flights from Panama City to Santiago?
Yes, this route has nonstop flights. Filter by "nonstop" to see them.
Which airlines fly from Panama City to Santiago?
Copa Airlines operate this route, among others. Compare them all in the results.
When should I book Panama City–Santiago flights?
As a rule of thumb, booking 3–8 weeks ahead and avoiding weekends and holidays tends to give the best prices. Use the calendar to spot the cheapest dates.