Cheap flights from Panama City to Santiago
from 380 US$

From 617 USD — compare hundreds of airlines

We search 100+ flight sitesDirect flights~6h 31mReturn route: Santiago → Panama City

The cheapest month is usually 2026-09 · 380 US$

Live fares from 100+ sites — free, with no hidden fees.

About this route

Compare flights from Panama City to Santiago, a about 4,810 km route (around 6h 31m nonstop). We gather live prices from hundreds of airlines and agencies so you can find the cheapest and book on the official site, with no hidden fees. Direct flights are available. Airlines such as Copa Airlines operate this route.

Nonstop time

6h 31m

Distance

4,810 km

Stops

Nonstop

Airlines

The airports on this route

Panama City

Aeropuerto Internacional de TocumenPTY

About 25 km from downtown Panama City

Getting around: Metro + buses, authorized taxis and apps

Copa’s big connection hub: if you’re only connecting you rarely need to leave the airport.

Santiago

Aeropuerto Internacional Arturo Merino BenítezSCL

About 20 km from downtown Santiago, in Pudahuel

Getting around: Official buses, shared transfers, authorized taxis and apps

When to buy and when to fly

Prices by date

Fares found by date — cheapest days in green.

See prices for my dates →

380 US$

25/09

How to get the best price

1The sticker price is real — but it moves fastLow fares last hours or days. If the number works, search it today; waiting rarely improves it.

2Buy 4–8 weeks aheadThat window usually holds the best fares; holidays call for even more margin.

3Flexibility = moneyShifting departure 2–3 days can move the fare 100+ US$. Tuesdays and Wednesdays tend to be cheap.

Airlines on this route

Copa Airlines

FAQ

What's the cheapest month to fly Panama City to Santiago?

It's usually 2026-09, from 380 USD. Use the price calendar to compare other dates.

How long is the flight from Panama City to Santiago?

A nonstop flight takes about 6h 31m and covers around 4,810 km. Connecting itineraries take longer.

Are there direct flights from Panama City to Santiago?

Yes, this route has nonstop flights. Filter by "nonstop" to see them.

Which airlines fly from Panama City to Santiago?

Copa Airlines operate this route, among others. Compare them all in the results.

When should I book Panama City–Santiago flights?

As a rule of thumb, booking 3–8 weeks ahead and avoiding weekends and holidays tends to give the best prices. Use the calendar to spot the cheapest dates.